- Daniel Böhmer, Dr. med., approval of the research project "Molecular mechanisms of mitochondrial RNA recognition by protein kinase R (PKR) - new target structure for treatment of interferonopathies?" by the Foundation Commission of the Medical Faculty (11.435 Euro).
- Adrian Gottschlich, Dr. med., obtained funding from the Bavarian Cancer Research Center (BZKF).
- Julia Rossi, M. Sc., successfully defended her master thesis at the University of Bordeaux.
- Thaddäus Strazalkowski, cand. med., was accepted to the Mildred-Scheel-Graduate Program of the Deutsche Krebshilfe.
- Sophia Stock, Dr. med., aced her paper on a new modular CAR T cell platform in JITC, congratulations to Sophia Stock, Mohamed-Reda Benmebarek and the team.
- Sebastian Kobold, Prof. Dr. med., has been awarded the Monika Kutzner Stiftung zur Förderung der Krebsforschung 2022.
- Adrian Gottschlich, Dr. med., the grant proposal at "Forschung und Lehre (FöFoLe) der Medizinischen Fakultät der LMU München" was accepted (59.776 Euro)
- Sebastian, Kobold, Prof. Dr. med.,
- Philipp, Müller, cand. med., was accepted to the Mildreed-Scheel-Scholar Program of the German Cancer Aid to fund his thesis project.
- Michael Wenzel, PD Dr. med. (doctoral degree in 2012), now University of Bonn, was awarded an ERC starting grant studying entire epileptic therapy, funded with 1.5 Mio Euro.
- Sebastian Kobold, Prof. Dr. med.: The Else-Kröner-Fresenius-Foundation has selected the physician scientist program "immunooncology and local interventions" (IOLIN) for funding. This program is headed by Professor Sebastian Kobold and co-headed by Professor Kirsten Lauber and Professor Michael von Bergwelt. IOLIN will start its work in 2022.
Carolin Daniel, Prof. Dr.: Winner of the Isil Berat Barlan Award for Women Scholars in Immunology – grant on the 3rd of September at the European Congress of Immunology (ECI, online) by Prof. Chatila (Children´s Hospital, Boston).
Bruno Cadilha, Ph. D., our collaborative work with the Mempel and Pittet laboratories was just released in Cell and adds on the biological rationale to use the CXCR6-CXCL16 axis to treat cancer using T cells.
This is the press release from MGH on the article:
Most forms of cancer immunotherapy rely on the anti-tumor activities of cytotoxic T lymphocytes (CTL) that can recognize and destroy cancer cells. CTL are first activated in tumor-draining lymph nodes, from where they reach tumors via the bloodstream. However, in contrast to lymph nodes, tumors are very hostile environments for T lymphocytes.
In this study, we found that in order to survive in tumors, CTL must spend time in specific survival niches that form directly adjacent to some of the blood vessels in the tumor stroma, which is the tissue surrounding the cancer cells. Within these niches, they are able to interact with a highly activated population of so-called dendritic cells that most effectively provide survival signals, such as the cytokine IL-15, that CTL depend on. IL-15 and other signals enable CTL to survive for long enough to effectively eliminate cancer cells and, under ideal conditions, reject the tumors entirely.
We were also wondering how the CTL find their way into these survival niches and are then retained there for long enough. For this we focused on chemokines, which are chemotactic guidance factors that direct the migration of immune cells and also helps them to “smell” and find each other in the vast expanses of our tissues. We discovered that one chemokine called CXCL16 is highly expressed by those activated dendritic cells that occupy the vessel-associated niches, and that the receptor for this niche, called CXCR6, helps CTL to accumulate in the niches and is thereby critical for their survival in tumors.
The newly gained insight into this mechanism will hopefully contribute to the development of more effective immunotherapies for cancer patients. One of the research groups involved, in parallel studies, already engineered T lymphocytes to express more CXCR6 and found that this increased their ability to control tumor growth in animal models of cancer.
- Lars König, Dr. rer. nat.:
- Lars König, Dr. rer. nat. und Daniel Böhmer: Pressemitteilung LMU Klinikum:
- Sebastian Kobold, Prof. Dr. med.: Pressemitteilung LMU Klinikum:
- Cadilha B et al.: Our manuscript "Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors " has just been released at Science Advances (JIF 13,2). Congratulations to Bruno and Mohamed-Reda for a breakthrough story.
- Lesch S et al.: Publication "T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours " has been published at Nature Biomedical Engineering (JIF 19,0), congratulation to Steffi, Vicky and Adrian who led the revision and of course the multinational team.
- Briukhovetska D et al.: Publication "Interleukins in cancer: from biology to therapy" has been published at Nature Reviews in Cancer (JIF 53,0), congratulations to Daria and Janina for this incredible effort.
- Sebastian Kobold, Prof. Dr. med., the collaborative research group TRR338 headed by Dirk Busch (TUM) has been selected for funding by the DFG. Prof. Sebastian Kobold is a coapplicant and project leader, congratulations.
- Sebastian Kobold, Prof. Dr. med., a team headed by Sebastian Kobold has received funding from the German Ministry for Research and Education (BMBF) in the program confirmatory preclinical studies. The team is constituted of Anne-Laure Boulesteix from the IBE at the LMU and Hinrich Abken from the Center for Interventional Immunology in Regensburg.
- Carolin Daniel, Prof. Dr., has been awarded with the Ferdinand Bertram Preis by the Deutsche Diabetesgesellschaft (DDG).
- Gabriela Wiedemann, Dr. med. (doctoral degree in 2014), now Department of Medicine II, Technical University of Munich, was awarded an Emmy Noether Nachwuchsgruppe by the Deutsche Forschungsgemeinschaft.
- Jan Gärtig, M. Sc., was selected for a doctoral scholarship by Cusanuswerk.
- Andrea Ablasser, Prof. Dr., we congratulate Andrea Ablasser, medical doctoral student in our division from 2005 to 2010, now associated Professor, École Polytechnique Fédérale de Lausanne, to receive the Deutsche Krebspreis (experimentelle Forschung) 2021.
- Carolin Daniel, Prof. Dr. phil. nat.., has been awarded funding by the Heinz Bürger-Büsing-Foundation.
- Carolin Daniel, Prof. Dr. phil. nat., continued funding in SFB 1054 “Control and Plasticity of Cell-Fate Decisions in the Immune System” (Speaker Prof. Dr. Thomas Brocker) 2021 to 2024, for project B11 “Mechanisms of immne activation vs. tolerance in autoimmune type 1 diabetes” with 467.000 Euro.
- Carolin Daniel, Prof. Dr. phil. nat., has been awarded funding by the EFSD (European foundation for the study of diabetes) Research Award.
- Lars König, Dr. rer. nat., was elected as a new member to the Transregio 237 „Nucleic Acid Immunity“, funded by the German Research Foundation (DFG).
- Mohamed-Reda Benmebarek, the manuscript on the use of the SAR T cell platform in acute myeloid leukemia has been accepted for publication in Leukemia. Congratulations to Reda and his team.
- Natascha Röhrle, cand. med. (1. Prize) and Matthias Seifert, cand. med. (2. Prize) were highly successful in the abstract competition of the doctoral project information day (DoktaMed) of the Medical Faculty on October24th 2020. This year the DoktaMed was held as a video conference with the impressive number of 400 on-line participants. Three prize winning abstracts were selected from forty submissions. Two of these prizes went to the Klin-Pharm.
- Hadi Karimzadeh, Dr. rer. nat., Preisträger der Deutschen Leberstiftung 2020.
- Öykü Umut, Ärztin, was awarded a doctoral stipend from the Deutsche Krebshilfe.
- Sebastian Kobold, Prof. Dr. med., the European Commission has announced that the Consortium T-OP (Training Network for Optimizing Adoptive T cell Therapy) has been selected for funding by the Marie-Sklodowska-Curie actions.
- Sebastian Kobold, Prof. Dr. med., has been awarded funding by the Fritz-Bender-Foundation.
- Lars König, Dr. rer. nat., Bewilligung DFG-Einzelantrag: Molekulare Mechanismen der Zelltodinduktion durch doppelsträngige 5‘-Triphosphat-RNA über 289.450 Euro.
- Carolin Daniel, Prof. Dr. phil. nat., will be awarded for the 2020 IUIS Early Career Research Prize in Vaccinology R&D (10.000 Euro).
- Simon Rothenfußer, Prof. Dr. med., Pressemitteilung: Parameter für einen guten Impfstoff.
- Stephan Kruger, Dr. med. (7.000 Euro) and Hadi Karimzadeh, Dr. rer. nat. (8.000 Euro), were awarded funding by the Friedrich Baur Foundation.
- Bruno Cadilha, Arzt, Förderung durch die Deutsche Gesellschaft für Immun- und Targeted Therapie.
- Hadi Karimzadeh, Dr. rer. nat., was awarded the German Liver Foundation (Deutsche Leberstiftung) Prize 2020 for his work in the field of Hepatology and his publication “Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level” in Gastroenterology.
- Phlipp Metzger, Ph. D., bewilligter Antrag auf Förderung des Forschungsvorhabens "Einfluss des Tumor Immune Microenvironment (TIME) auf das Ansprechen RIG-I-basierter Immuntherapie im Pankreaskarzinom“ Verein zur Förderung von Wissenschaft und Forschung (WiFoMed).
- Prof. Dr. med. Sebastian Kobold, 5th of february 2020: The German Ministry of Research and Education has announced the finalist of the "Cluster4future" initiative, the new flagship-program of the BMBF. Out of 137 proposals, the jury has selected 16 or the final round.
- The Munich Cluster to Enable Personalized Cellular Therapies (PerCELLuM), as only bavarian life science cluster, is among the finalists. PerCELLuM is a joint cluster of the Ludgwig-Maximilians-Universität München and the Technische Universität München with significant contributions from the Helmholtz Center Munich. PerCELLuM is jointly led by Univ.-Prof. Dr. med. Sebastian Kobold (LMU and KUM) and Univ.-Prof. Dr. med. Dirk Busch (TUM and MRI).
- Sebastian Kobold, Prof. Dr. med. will be awarded the Clinician Science Award 2020 by the Deutsche Gesellschaft für Immun- und Targeted Therapie on January 31st 2020.
- Stefan Endres, Prof. Dr. med., Wahl in den Vorstand des Wissenschaftlichen Beirats der Bundesärztekammer.
- Bruno Cadilha, Arzt, Verleihung des Forschungspreis Young Scientists IO der Bristol-Myers Squibb-Stiftung Immunonkologie.
- Sebastian Kobold Prof. Dr. med. and Bruno Cadilha, Arzt, were awarded for the m4 Award with the thesis „Entwicklung einer T-Zelltherapieplattform um chimäre Antigenrezeptor (CAR) T-Zellen und andere zelltherapeutische Verfahren vor Suppression zu schützen und regulatorische Mechanismen zur Funktionsverstärkung einzusetzen - CARMOUFLAGE“.
- Sebastian Kobold, Prof. Dr. med. was awarded funding by the Jose Carreras foundation and the Hector foundation.
- Carolin Daniel, Prof. Dr. phil. nat., Preisträgerin des Nils-Ilja-Richter Preis 2019 der Deutschen Autoimmunstiftung.
- Britta Siegmund, Prof. Dr. med., former doctoral student and post-doc (1995 to 2000) of the Division of Clinical Pharmacology, since 2013 Chair of Gastroenterology, Charité, Berlin, was elected Vice President of the Deutsche Forschungsgemeinschaft.
- David Anz, PD Dr. med., Bewilligung des DFG-Einzelantrags "Bedeutung des Chemokins CCL22 in der Aufrechterhaltung immunologischer Toleranz"; Förderung 241.000 Euro über drei Jahre.
- Hadi Karimzadeh, Dr. rer. nat. was awarded the Junior Researcher Fund by the LMU Excellent program
- Prof. Dr. med. Sebastian Kobold: Bewilligung des DFG-Einzelantrags "Rolle von Interleukin-22 in der Metastasierung des Mamma- und Lungenkarzinoms"; Förderung 370.000 Euro über drei Jahre.
- Prof. Dr. med. Sebastian Kobold: appointed W2-Professor for Experimental Immunoncology in the Division of Clinical Pharmacology.
- Our manuscript describing a novel cell therapy platform, the synthetic agonist receptor (SAR) T cells for cancer therapy was accepted in Clinical Cancer Research (JIF 10.2). Congratulations to Clara and Reda who spearheaded this work!
- Our manuscript on breast cancer metastasis and the functional link to breast cancer phenotype has appeared online at Science Advances (JIF 11.5). Congratulation to Bruno, Ana, Conny, Daria and Javi for their outstanding contributions.
- Prof. Dr. phil. nat. Carolin Daniel: appointed W2-Professor for Immunmodulation in the Division of Clinical Pharmacology (will continue leading the group Immunotolerance at the Institute for Diabetic Research, Helmholtz Zentrum Munich).
- Stefanie Lesch, M. Sc. won the "Posterpreis" – presented by Lena Völkl – at the ITOC Congress 2019 in Vienna.
Manuscript PD Dr. med. David Anz: CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes. Journal of Experimental Medicine 2019; 116:5514-5522. JIF 10.8.
PD Dr. med. Sebastian Kobold receives the Johann-Georg-Zimmermann Award for Cancer Research 2019.
- Prof. Dr. med. Stefan Endres: member of the scientific advisory board (Wissenschaftlicher Beirat) of the "Bundesärztekammer".
- Manuscript Rataj et al. "High affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy" was accepted for publication in the British Journal of Cancer. Congratulations to the team and special thanks to Justyna Ogonek and Nicholas Tokarew who took care of the revision.
- DFG approval for purchasing an in vivo imaging system IVIS (e. g. for in vivo quantification of tumor growth); 361.000 Euro will be financed at 50 % each by the DFG and by the University Hospital.
- The manuscript "PD1-CD28 fusion protein enables CD4+ T cell help for adoptive T cell therapy in models of pancreatic cancer and non-Hodgkin-lymphoma" was accepted for publication in Frontiers in Immunology 2018. Congratulations to Felicitas Rataj, Fabian Kraus and their team.
- Dr. Julia Ahlfeld and Ph. D. Jin Zhang were awarded funding by the Friedrich Baur Foundation.
- Three members of the Division have been granted funding as Principal Investigators within one renewed and two new Collaborative Research Centers (Sonderforschungsbereiche) der Deutschen Forschungsgemeinschaft: Simon Rothenfußer, Prof. Dr. med. SFB-Transregio 237 “Nukleinsäure-Immunität” (Bonn, München und Dresden); Max Schnurr, Prof. Dr. med., SFB 1321 “Modellierung und Targeting des Pankreaskarzinoms”; and Peter Düwell, PD Dr. biol. hum. SFB 1123: “Athersklerose: Mechanismen und Netzwerke therapeutischer Zielstrukturen”.
- Stefan Endres, Prof. Dr. med., appointed as Member of the Kuratorium (Board of Trustees) des Deutschen Museums München.
Congratulations to Anamarija Markota, Dr. rer. nat., Adrian Gottschlich, cand. med. and Felicitas Rataj, Dr. for their articles accepted in Human Vaccines and Immunotherapies, Translational Cancer Research and Translation Lung Cancer Research!
Justyna Ogonek was awarded funding from the "Verein zur Förderung von Wissenschaft und Forschung an der Medizinischen Fakultät der LMU", congratulations!
- Der Immunologe Veit Hornung, Prof. Dr. med., klärt zentrale Abwehrmechanismen des angeborenen Immunsystems auf. Jetzt bekommt er für seine Arbeiten den wichtigsten deutschen Forschungspreis: den Leibniz-Preis 2017 der Deutschen Forschungsgemeinschaft. Veit Hornung hat in der Abteilung für Klinische Pharmakologie promoviert und war Postdoktorand in der Abteilung (DE/SZ.de).
- Simon Rothenfusser, Prof. Dr. med.: Gemeinsamer Projektantrag mit Anne Krug (LMU) und Giovanna Barba-Späeth (Institut Pasteur, Paris) im Rahmen der ANR-DFG Cooperation 2017 in Natural, Life and Engineering Sciences bewilligt.
- Felicitas Rataj Dr., has been awarded a 2-year fellowship from Peter-and-Traudl-Engelhorn Foundation.
Lars König, Dr. rer. nat.: Antrag auf Projektförderung bei der Else Kröner Fresenius-Stiftung in Höhe von 297.973 Euro wurde bewilligt.
Sebastian Kobold, PD Dr. med. mit ERC Starting Grant ausgezeichnet (DE).
On July 7th the Division welcomed as a guest Prof. Jules Hoffmann, Université de Strasbourg. Prof. Hoffmann is a world leader in innate immunity. He received the Nobel Prize in Physiology and Medicine in 2011 for his discovery of the toll system in insects.
Sebastian Kobold, PD Dr. med. und Stefan Endres, Prof. Dr. med.: Antrag Onkattract beim Bundesministerium für Bildung und Forschung, Projektträger Jülich wurde mit 1.202.588 Euro bewilligt.
- Adrian Gottschlich, cand. med., was selected for the "Studienstiftung des deutschen Volkes".
- Severin Jacobi, cand. med., was selected for a Jose-Carreras-Foundation doctoral student fellowship.
- Angelina Krächan, cand. med., was selected for a Mildreed-Scheel-Foundation doctoral student fellowship.
- Sebastian Kobold, PD Dr. med., was awarded the Hugo-Wilhelm-von Ziemssen-Award
- for medical research.
- Sebastian Kobold, PD Dr. med., received the Vincenz-Czerny Award 2016 by the German Society for Hematology and Medical Oncology.
- Max Knott, cand. med. and Moritz Schmidbauer, cand. med., were selected into the "MeCuM StEP - Studierende Exzellenz Programm" LMU.
- Cornelia Ochs, M. Sc., was awarded funding by the CIPSMwomen program.
- Stefan Stoiber, cand. med., was awarded funding by the LMUexcellent student research program.
- Our manuscript "Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases" was accepted for publication in BMC Cancer, congratulations to Amanda and her team.
- AG Anz was awarded funding by the Wilhelm-Sander-Stiftung.
- Felicitas Rataj, Dr., was awarded funding by the Friedrich Baur Foundation.
- Sebastian Kobold, PD Dr. med., was awarded funding by the LMUExcellent program.
- Marion Subklewe, Prof. Dr.: The Clinician Scientist Program Cancer Immunotherapy (CSP Munich) has been selected for funding by the Else Kröner Fresenius Stiftung. PD Dr. Sebastian Kobold is one of the PI of the program. Congratulations!
- Our manuscript "A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice" was accepted for publication in Oncoimmunology. Congratulations to Gabi Wiedemann and her team.
- Sebastian Kobold, PD Dr. med., receives the BMS-Melanoma Research Alliance Young Investigator Award.
- Sebastian Kobold, PD Dr. med., is awarded funding by the Verein zur Förderung von Wissenschaft und Forschung an der Medizinischen Fakultät der Ludwig-Maximilians-Universität München.
- Fabian Kraus, cand. med., is awarded a travel grant to the CIMT meeting 2016 in Mainz by the Studienstiftung des Deutschen Volkes.
Dr. Felicitas Rataj is awarded funding from the CIPSM Gender Program.
Stefanie Lesch, M. Sc., is awarded funding from the CIPSM Gender Program.
Clara Karches, Dipl.-Biochem., is awarded funding from the CIPSM Gender Program.