Model based Dose Calculation for Liver Brachytherapy
At the Department of Radiation Oncology of the University Hospital of the LMU Munich, over 100 highly specialized liver brachytherapy procedures are performed each year. Our group is exploring, with Dr. med. Stefanie Corradini, the use of model-based dose calculations for this entity, which is particularly important given the proximity of low-density lung tissue, as well as the liver’s higher-than-water density. In partnership with Maastro (Profs F. Verhaegen and G.P Fonseca), we have used the AMIGOBrachy software platform to recalculate high-dose-rate liver brachytherapy plans using full Monte Carlo simulation of radiation interaction within the patients’ anatomy. We are additionally exploring the impact of respiratory motion on the brachytherapy dose distribution using time-resolved (4D) CT imaging and dose calculation. This project has attracted seed industry funding from Elekta as well as from the FöFoLe commission of the Medical Faculty of the LMU Munich.
- 1. Duque AS, Corradini S, Kamp F, Seidensticker M, Streitparth F, Kurz C, Walter F, Parodi K, Verhaegen F, Ricke J, Belka C., Fonseca, G.P., Landry, G. The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy. Radiation Oncology. 2020 Dec;15(1):1-1.