Forschungsergebnisse
Wissenschaftliche Publikationen aus dem GEPNET-KUM
2021
- Dosimetry and optimal scan time of [18F]SiTATE-PET/CT in patients with neuroendocrine tumours
- Antitumoral Activity of the MEK Inhibitor Trametinib (TMT212) Alone and in Combination with the CDK4/6 Inhibitor Ribociclib (LEE011) in Neuroendocrine Tumor Cells In Vitro
- Feasibility and Early Clinical Experience of Online Adaptive MR-Guided Radiotherapy of Liver Tumors
- Treatment of advanced gastroenteropancreatic neuroendocrine neoplasia, are we on the way to personalised medicine?
- Cost-Effectiveness Analysis of 68Ga DOTA-TATE PET/CT, 111In-Pentetreotide SPECT/CT and CT for Diagnostic Workup of Neuroendocrine Tumors
- Development of severe intrapulmonary shunting in a patient with carcinoid heart disease after closure of a persistent foramen ovale: a case report
- [Indications for the Surgical Management of Pancreatic Neuroendocrine Neoplasms]
- 68Ga-DOTATATE PET/CT and MRI with Diffusion-Weighted Imaging (DWI) in Short- and Long-Term Assessment of Tumor Response of Neuroendocrine Liver Metastases (NELM) Following Transarterial Radioembolization (TARE)
- Apparent diffusion coefficients (ADC) in response assessment of transarterial radioembolization (TARE) for liver metastases of neuroendocrine tumors (NET): a feasibility study
2020
- Radiosynthesis of [18F]SiFAlin-TATE for clinical neuroendocrine tumor positron emission tomography
- Automated production of [18F]SiTATE on a Scintomics GRP™ platform for PET/CT imaging of neuroendocrine tumors
- Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity
- [Indications for the Surgical Management of Pancreatic Neuroendocrine Neoplasms]
- Management of Asymptomatic Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms (ASPEN) ≤2 cm: Study Protocol for a Prospective Observational Study
- Distinct Expression Patterns of VEGFR 1-3 in Gastroenteropancreatic Neuroendocrine Neoplasms: Supporting Clinical Relevance, but not a Prognostic Factor
- Radioembolization for neuroendocrine liver metastases is safe and effective prior to major hepatic resection
- Inhibition of Wnt/β-Catenin Signaling in Neuroendocrine Tumors in vitro: Antitumoral Effects
- Biodistribution and first clinical results of 18F-SiFAlin-TATE PET: a novel 18F-labeled somatostatin analog for imaging of neuroendocrine tumors
- Toxicity of a combined therapy using the mTOR-inhibitor everolimus and PRRT with [177Lu]Lu-DOTA-TATE in Lewis rats
2019
- [Current standards and novel developments in the treatment of neuroendocrine tumors of the gastroenteropancreatic system]
- [Pulmonary carcinoids and carcinoids of the small intestine]
- [Neuroendocrine tumors of the stomach, duodenum and pancreas : Value of (hybrid) radiological diagnostics]
- Salvage PRRT with 177Lu-DOTA-octreotate in extensively pretreated patients with metastatic neuroendocrine tumor (NET): dosimetry, toxicity, efficacy, and survival
- Indications for resection and perioperative outcomes of surgery for pancreatic neuroendocrine neoplasms in Germany: an analysis of the prospective DGAV StuDoQ|Pancreas registry
- Treatment with somatostatin analogs induces differentially expressed let-7c-5p and mir-3137 in small intestine neuroendocrine tumors
- Combination of 5-Fluorouracil with Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, and Radioligand Binding in Neuroendocrine Tumor Cells In Vitro
- Immune checkpoint markers in gastroenteropancreatic neuroendocrine neoplasia
2018
- [Oligometastases of neuroendocrine tumors-extent of surgery]
- Advanced neuroendocrine tumours of the small intestine and pancreas: clinical developments, controversies, and future strategies
- Supportive therapy in gastroenteropancreatic neuroendocrine tumors: Often forgotten but important
- [Practice guideline neuroendocrine tumors - AWMF-Reg. 021-27]
- [Neuroendocrine Neoplasia within the German NET Registry]
- Identification and characterization of myocardial metastases in neuroendocrine tumor patients using 68Ga-DOTATATE PET-CT
- Surgical treatment of pNET - Experience of a "high-volume" center
- Neuroendocrine tumors of the small intestine causing a desmoplastic reaction of the mesentery are a more aggressive cohort
- The role of GSK3 and its reversal with GSK3 antagonism in everolimus resistance
- Tropomyosin receptor kinase: a novel target in screened neuroendocrine tumors
2017
- Advanced neuroendocrine tumours of the small intestine and pancreas: clinical developments, controversies, and future strategies
- GSK3α/β: A Novel Therapeutic Target for Neuroendocrine Tumors
- The selective PI3Kα inhibitor BYL719 as a novel therapeutic option for neuroendocrine tumors: Results from multiple cell line models
- The Novel Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) Alone and in Dual-Targeting Approaches Demonstrates Antitumoral Efficacy in Neuroendocrine Tumors in vitro
- The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells
- Pre-therapeutic factors for predicting survival after radioembolization: a single-center experience in 389 patients
- The Impact of Somatostatin Receptor-Directed PET/CT on the Management of Patients with Neuroendocrine Tumor: A Systematic Review and Meta-Analysis
- [Neuroendocrine neoplasia of the stomach : What is new?]
- Survival prediction in patients undergoing radionuclide therapy based on intratumoral somatostatin-receptor heterogeneity
- Efficacy of peptide receptor radionuclide therapy with 177Lu-octreotate in metastatic pulmonary neuroendocrine tumors: a dual-centre analysis
2016
- The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1
- Survival prediction in patients undergoing radionuclide therapy based on intratumoral somatostatin-receptor heterogeneity
- Nephroprotective effects of enalapril after [177Lu]-DOTATATE therapy using serial renal scintigraphies in a murine model of radiation-induced nephropathy
- Effectiveness and side-effects of peptide receptor radionuclide therapy for neuroendocrine neoplasms in Germany: A multi-institutional registry study with prospective follow-up
- The added value of 68Ga-DOTA-TATE-PET to contrast-enhanced CT for primary site detection in CUP of neuroendocrine origin
- RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors
- Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
2015
- Additive Anti-Tumor Effects of Lovastatin and Everolimus In Vitro through Simultaneous Inhibition of Signaling Pathways
- Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for 'Off-Target' Effects Not Mediated by c-Met Inhibition
- Predictive Value of 99mTc-MAA SPECT for 90Y-Labeled Resin Microsphere Distribution in Radioembolization of Primary and Secondary Hepatic Tumors
- Impact of (68)Ga-DOTATATE PET/CT on the surgical management of primary neuroendocrine tumors of the pancreas or ileum
2014
- Intestinal neuroendocrine cells and goblet cells are mediators of IL-17A-amplified epithelial IL-17C production in human inflammatory bowel disease
- Anticancer effects of metformin on neuroendocrine tumor cells in vitro
- Towards new response criteria in neuroendocrine tumors: which changes in MRI parameters are associated with longer progression-free survival after radioembolization of liver metastases?
- [Neuroendocrine neoplasms of the distal jejunum and ileum]
- Treatment with octreotide in patients with well-differentiated neuroendocrine tumors of the ileum: prognostic stratification with Ga-68-DOTA-TATE positron emission tomography
- Treatment with octreotide in patients with well-differentiated neuroendocrine tumors of the ileum: prognostic stratification with Ga-68-DOTA-TATE positron emission tomography
- Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells
2013
- Diagnostic accuracy of dynamic gadoxetic-acid-enhanced MRI and PET/CT compared in patients with liver metastases from neuroendocrine neoplasms
- Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells
- Neuroendocrine tumor recurrence: diagnosis with 68Ga-DOTATATE PET/CT
- Evaluation of neuroendocrine liver metastases: a comparison of dynamic contrast-enhanced magnetic resonance imaging and positron emission tomography/computed tomography
- Defining predictors for long progression-free survival after radioembolisation of hepatic metastases of neuroendocrine origin
- The novel somatostatin receptor 2/dopamine type 2 receptor chimeric compound BIM-23A758 decreases the viability of human GOT1 midgut carcinoid cells
2012
- Comparison of abdominal MRI with diffusion-weighted imaging to 68Ga-DOTATATE PET/CT in detection of neuroendocrine tumors of the pancreas
- [Gastrointestinal mixed adenoneuroendocrine carcinomas. An attempt at classification of mixed cancers]
- Fluid-fluid level in hepatic metastases: a characteristic sign of metastases of neuroendocrine origin
- Combined quantification of liver perfusion and function with dynamic gadoxetic acid-enhanced MR imaging
- Peptide receptor radionuclide therapy for neuroendocrine tumors in Germany: first results of a multi-institutional cancer registry
- The role of 68Ga-DOTATATE PET/CT in suspected neuroendocrine tumors
- [Neuroendocrine tumours of the GI tract--data from the German NET Registry]
- Perifosine-mediated Akt inhibition in neuroendocrine tumor cells: role of specific Akt isoforms
- [Medicinal therapy of metastasized neuroendocrine tumors of the gastroenteropancreatic system]
- [Gastroenteropancreatic neuroendocrine tumors: diagnosis and therapy in nuclear medicine]
- Radioembolization of symptomatic, unresectable neuroendocrine hepatic metastases using yttrium-90 microspheres
2011
- Fluid-fluid level in hepatic metastases: a characteristic sign of metastases of neuroendocrine origin
- Treatment with octreotide does not reduce tumor uptake of (68)Ga-DOTATATE as measured by PET/CT in patients with neuroendocrine tumors
- Therapeutic strategies for advanced neuroendocrine carcinomas of jejunum/ileum and pancreatic origin
- The novel Raf inhibitor Raf265 decreases Bcl-2 levels and confers TRAIL-sensitivity to neuroendocrine tumour cells
- Arterial therapies of non-colorectal cancer metastases to the liver (from chemoembolization to radioembolization)
- Contrast agents as a biological marker in magnetic resonance imaging of the liver: conventional and new approaches
2010
- [Progressive dyspnoea in two patients with carcinoid syndrome]
- Compensatory activation of Akt in response to mTOR and Raf inhibitors - a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease
- 68Ga-DOTATATE PET/CT for the early prediction of response to somatostatin receptor-mediated radionuclide therapy in patients with well-differentiated neuroendocrine tumors
- [Quantification of immunohistochemical expression of somatostatin receptors in neuroendocrine tumors using 68Ga-DOTATATE PET/CT]
- Radiofrequency ablation after selective internal radiation therapy with Yttrium90 microspheres in metastatic liver disease-Is it feasible?
- Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency
2009
- [Liver metastases from neuroendocrine tumours of the gastroenteropancreatic system--therapeutic strategies]
- Intraindividual comparison of 68Ga-DOTA-TATE and 18F-DOPA PET in patients with well-differentiated metastatic neuroendocrine tumours
- [Gastrointestinal oncology - therapy update 2008 / 2009]
- [Characteristic imaging features of carcinoid tumors of the small bowel in MR enteroclysis]