Prof. Dr. med. Johannes Levin
Univ.-Prof. Dr. med. Johannes Levin
Neurologische Klinik LMU Klinikum Klinikum Großhadern
81377 München
Aufgaben in der Neurologischen Klinik
Professur Klinische Neurodegeneration
Leiter der Ambulanzen für kognitive Neurologie und für Bewegungsstörungen
Oberarzt Station H8
Klinische Qualifikationen
Facharzt für Neurologie
Zusatzbezeichnung Neurologische Intensivmedizin
Fachspezifische genetische Beratung Neurologie
EEG Zertifikat der DGKN
Zertifikat: „Qualifizierte Botulinumtoxin Therapie“ der AG Botulinumtoxin der DGN
Klinische Schwerpunkte
Parkinson-Krankheit und andere Bewegungsstörungen
Alzheimer-Krankheit und andere Demenzen
Neurologische Intensivmedizin
Wissenschaftliche Schwerpunkte
Synucleinopathien (Parkinson und MSA)
Tauopathien (PSP und CBS)
Erkrankungen mit Alzheimer Pathologie – Fokus auf genetische Formen
Weitere genetische Demenzen
Entwicklung verlaufsmodifizierender Therapien
- Bernhardt AM, …, Levin J. A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases. EBioMedicine. 2023 Mar;89:104456.
- Levin J. et al., Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: a randomised, double-blind, placebo-controlled phase 1a trial. EBioMedicine. 2022;80:104021.
- Levin J. et al., Testing the amyloid cascade hypothesis: Prevention trials in autosomal dominant Alzheimer disease. Alzheimers Dement. 2022 Dec;18(12):2687-2698.
- Vöglein J, …, Levin J. Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimers Dement. 2023 Feb;19(2):632-645.
- Barthélemy NR, …, Levin J, …, McDade E. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nat Med. 2020 Mar;26(3):398-407.
- Levin J. et al., Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2019 Aug;18(8):724-735.
- Vöglein J, …, Levin J. Clinical, pathophysiological, genetic features of motor symptoms in autosomal dominant AD. Brain. 2019 May 1;142(5):1429-1440.
- Preische O, …, Levin J, …, Jucker M, Dominantly Inherited Alzheimer Network. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s Disease. Nature Medicine. 25:277-283.
- Höglinger GU, ..., Levin J, …, Litvan I; Movement Disorder Society-endorsed PSP Study Group. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord. 2017 Jun;32(6):853-864.
- Levin J, et al., The Differential Diagnosis and Treatment of Atypical Parkinsonism. Dtsch Arztebl Int. 2016 Feb 5;113(5):61-9.
- Segovia F, …, Levin J. Distinguishing Parkinson's disease from atypical parkinsonian syndromes using PET data and a computer system based on support vector machines and Bayesian networks. Front Comput Neurosci. 2015 Nov 5;9:137.
- Levin J, et al., The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset. Acta Neuropathol. 2014 May;127(5):779-80.
- Wagner J*, Ryazanov S*, Leonov A*, Levin J*, …, Giese A. Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 2013 Jun;125(6):795-813.