AG Marschner (Nephrotoxicity)

Julian Marschner is a postdoctoral fellow at the Department of Medicine IV of the University Hospital, LMU Munich. He works on pre-clinical in vitro and in vivo models of acute kidney injury (AKI) and chronic kidney disease (CKD), thereby focusing on the interplay between the immune system and the renal parenchyme in mechanisms of tissue injury and regeneration. Specifically, his research looks into the role of soluble receptors of the immune system (e.g. PTX3, NLRP3) in non-immune cells of the kidney and the contribution to the progression of kidney disease. He further puts emphasis on the development of sophisticated cell culture models to mimic key aspects of AKI and CKD, and the development of therapeutic strategies to foster parenchymal recovery after injury.

Qualifications

• Doctoral degree in human biology, LMU Munich (2019)
• M.Sc. Environmental Toxicology, University of Trier (2013)
• B.Sc. Geography and Environmental Sciences, University of Freiburg/ LMU Munich (2009)

Biography

Julian Marschner ended his studies in Geography and Environmental Sciences with a strong focus on the impact of human actions on forestal and edaphic processes, qualifying with a BSc in 2009. This prompted him to widen his scope on the interplay between man and nature on a molecular level, which led him to further study Environmenal Toxicology, finishing with a MSc in 2013. His education at the University of Trier focused his interest on the role of the mammalian immune system in developing adverse reactions to human- and nature-derived small molecules.

Having identified studies on the mammalian immune system as a passion, he sought to deepen his knowledge in the field by getting in touch with clinical aspects of immunity. In doing so he enrolled at Hans-Joachim Anders group as a PhD student in 2013 and studied the contribution of the immune system to various pre-clinical models of AKI and CKD in the subsequent years, qualifying for a doctoral degree in 2019.

From there on he continued working with Prof. Anders on questions of renal injury and regeneration in pre-clinical models of kidney disease as a Postdoctoral fellow. His primary focus lies in identifying potential therapeutic targets and validating respective experimental interventions in the context of acute and chronic kidney disease.

Teaching

• Using R in biomedical research

Research

• Murine models of acute kidney injury (AKI) and chronic kidney disease (CKD)
• Means and strategies to increase the reliability of renal ischemia and reperfusion injury induction in mice
• Role of PTX3 in different models of AKI and CKD
• Role of the NLRP3-inflammasome in the context of renal crystallopathies and its functionality in immune and non-immune cells
• Identifying and validating therapeutic strategies to target renal progenitor cells to foster parenchymal healing after severe injury
• Developing sophisticated 3D co-culture systems to mimic key aspects of renal injury in vitro

Other activities

• Review editor Frontiers in Pharmacology

Publications

Recent publications

Article

Motrapu M, Świderska MK, Mesas I, Marschner JA, Lei Y, Martinez Valenzuela L, Fu J, Lee K, Angelotti ML, Antonelli G, Romagnani P, Anders HJ, Anguiano L. Drug Testing for Residual Progression of Diabetic Kidney Disease in Mice Beyond Therapy with Metformin, Ramipril, and Empagliflozin. J Am Soc Nephrol. 2020 Aug 31. doi: 10.1681/ASN.2019070703. PMID: 32576600

Salei N, Rambichler S, Salvermoser J, Papaioannou NE, Schuchert R, Pakal¬niškytė D, Li N, Marschner JA, Lichtnekert J, Stremmel C, Cernilogar FM, Sal¬vermoser M, Walzog B, Straub T, Schotta G, Anders HJ, Schulz C, Schraml BU. The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subty¬pes throughout Development That Differ in Their Inflammatory Properties. J Am Soc Nephrol. 2020 Jan 13. pii: ASN. 2019040419. doi: 10.1681/ASN.2019040419. PMID: 31932472.

Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Che¬vre R, Marschner J, et.al. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature. 2019 May;569(7755):236-240. doi: 10.1038/s41586-019-1167-6. Epub 2019 May 1. PMID: 31043745; Central PMCID: PMC6716525.

Marschner JA, Mulay SR, Steiger S, Anguiano L, Zhao Z, Boor P, Rahimi K, In¬forzato A, Garlanda C, Mantovani A, Anders HJ. The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease. Front Immunol. 2018 Sep 25;9:2173. doi: 10.3389/fimmu.2018.02173. eCollection 2018. PMID: 30319631; Central PMCID: PMC6167460.

Lazzeri E, Angelotti ML, Peired A, Conte C, Marschner JA, Maggi L, Mazzing¬hi B, Lombardi D, Melica ME, Nardi S, Ronconi E, Sisti A, Antonelli G, Becherucci F, De Chiara L, Guevara RR, Burger A, Schaefer B, Annunziato F, Anders HJ, Lasag¬ni L, Romagnani P. Endocycle-related tubular cell hypertrophy and proge¬nitor proliferation recover renal function after acute kidney injury. Nat Com¬mun. 2018 Apr 9;9(1):1344. doi: 10.1038/s41467-018-03753-4. PMID: 29632300; Central PMCID: PMC5890293.

Nakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, Kraft F, Lei Y, Fukasawa Y, Moeckel GW, Angelotti ML, Liapis H, Anders HJ. Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ In¬jury in Ischemic AKI. J Am Soc Nephrol. 2017 Jun;28(6):1753-1768. doi: 10.1681/ASN.2016080925. Epub 2017 Jan 10. PMID: 28073931; Central PMCID: PMC5461800.

Mulay SR, Eberhard JN, Desai J, Marschner JA, Kumar SV, Weidenbusch M, Grigorescu M, Lech M, Eltrich N, Müller L, Hans W, Hrabě de Angelis M, Vielhau¬er V, Hoppe B, Asplin J, Burzlaff N, Herrmann M, Evan A, Anders HJ. Hyperoxalu¬ria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disea¬se. J Am Soc Nephrol. 2017 Mar;28(3):761-768. doi: 10.1681/ASN. 2016040486. Epub 2016 Sep 9. PMID: 27612997; Central PM¬CID: PMC5328164.

Marschner JA, Schäfer H, Holderied A, Anders HJ. Optimizing Mouse Surge¬ry with Online Rectal Temperature Monitoring and Preoperative Heat Supply. Ef¬fects on Post-Ischemic Acute Kidney Injury. PLoS One. 2016 Feb 18;11(2):e0149489. doi: 10.1371/journal.pone.0149489. eCollection 2016. PMID: 26890071; Central PMCID: PMC4758659.

Mulay SR, Eberhard JN, Pfann V, Marschner JA, Darisipudi MN, Daniel C, Ro¬moli S, Desai J, Grigorescu M, Kumar SV, Rathkolb B, Wolf E, Hrabě de Ange¬lis M, Bäuerle T, Dietel B, Wagner CA, Amann K, Eckardt KU, Aronson PS, Anders HJ, Knauf F. Oxalate-induced chronic kidney disease with its uremic and cardio¬vascular complications in C57BL/6 mice. Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F785-F795. doi: 10.1152/ajprenal.00488.2015. Epub 2016 Jan 13. PMID: 26764204; Central PMCID: PMC5504458.