PhD student (m/f/d)

Our group focuses on both basic experimental and translational approaches to investigate the crosstalk between innate immune cells, platelets and plasmatic factors in the context of cardiovascular and infectious diseases

• You will use a broad range of in vitro and in vivo methods to dissect the interplay between neutrophils and platelets in the setting of both sterile and pathogen-driven inflammation
• State-of-the-art methods include transgenic mouse models with cell type-specific knockout mice, a broad range of clinically relevant models of cardiovascular disease and inflammation, superresolution in vivo microscopy as well as as multi-omics approaches including single-cell RNA sequencing, bulk RNA sequencing, multi-panel flow cytometry and proteomics
• You will be able to correlate and validate your experimental findings with clinical samples, comprising a broad biobank with hundreds of patients with cardiovascular diseases
• You will contribute to the acquisition of multi-omics data from cryoconserved patient-derived samples, working in close collaborations with clinicians to assess patient outcomes
• The Department of Cardiology is funded by and embedded into various collaborative research centers and graduate schools of the German Research Foundation (DFG), including the DFG CRC1123, CRC914. Further funding is provided by the Else Kröner-Fresenius-Stiftung and the European Research Council.
• You will present the results at project meetings and publish them in high-ranking scientific journals

• We require the applicant to have a major interest in cardiovascular immunology and innate immunity

• Previous experience with handling of mice, especially surgical techniques, is favoured
• Experience with the analysis of experimental data and high-throughput data ((sc)RNA-seq, proteomics, etc.) is a plus
• We expect strong communication and teamwork skills