Our working group investigates various aspects of intestinal inflammation, barrierdysfunctionandmicrobial colonizationas well as associated pathologies. These include dysbiosis, endotoxinemia, and the resulting chronic inflammation, which affectsourentireorganisminvariousways,e.g.,thegut-liveraxis, which connects the gut with the liver via the portal vein. Using ex vivo and in-vitro studies, we are aiming at characterizing luminal, portal-venous and systemic mediators and looking for new therapeutic targets. Another research focus are inflammatory bowel diseases (ulcerative colitis and Crohn's disease).

Current projects:

• IAP impact on NAFLD
• Gut barrier function in EOCRC