We are particularly interested in the contribution of nerves in the initiation process and progression of pancreatic cancer PDAC. In several carcinomas, neuronal signaling has been found to regulate relevant processes of cancer biology. Until recently, pancreatic cancer has not been in the focus of respective research. But in view of the incidence and poor prognosis of pancreatic cancer, new insights in biology and therapeutic strategies are of prime importance. Our work focuses on influences of the nervous system on pancreatic cancer in vitro and in vivo. Thereby we investigate effects proliferation and apoptosis of carcinoma cells as well as on interactions with tumor-microenvironment and dissemination and metastasis formation. We are working to facilitate the clinical realization of basic science principles in order to improve the care and treatment of pancreatic cancer patients.