i-Target 2.0 IOLIN seminar program

Results colloquium

Annika Jasper, AG Buchner

n.a

Journal club

Linda Hammann, AG Anz

n.a

Guest speaker

Dr. med. Michael Bscheider

Principal Scientist, Roche Holding AG

Human in vitro immunology in drug development

Results colloquium

Jakob Harwood, AG Kobold

Tumor-agnostic improvement of cellular therapies through drug-inducible chemokine receptor (DrICk-R) engineering

Journal club

Seoyoung Jang, AG Kobold

Reiss et al. CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial, Nature Medicine 2025

Guest speaker

Sébastien Wälchli, PhD

Senior scientist, group leader, Oslo University Hospital

Establishment of the first CAR factory in Norway

Results colloquium

Adriano Carboniero, AG Theurich

Modification of the functional and anti-cancer profile of Natural Killer cells subpopulations in the context of obesity and exercise

Journal club

Florian Jahrbeck, AG Rothenfußer

Cheng et al. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences, Nature Immunology 2023

Results colloquium

David Andreu Sanz, AG Kobold

RoseTTAFold binders as a powerful tool to leverage CAR T cell therapy

Journal club

Philipp Menauer, AG Kobold

Prasad et al. Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy, Blood 2025

Results colloquium

Viola Siegert, AG Buchner

Metabolic reprogramming in Richter Transformation

Journal club

Anja Hauptstein, AG Kobold

Silvia et al. CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual-targeting antibody overcome antigen heterogeneity in AML, Blood 2025

Results colloquium

Sabine Oganesian, AG Theurich

Multidimensional charazteriation of the microenvironment in CTCL with a special focus on B cells

Journal club

Ziting Zhang, AG Helfrich

Stejerean-Todoran et al. A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells, Neuro Oncol 2023

Results colloquium

Giulia Rappa, AG Subklewe

In vitro stimulation of T cells to fight AML

Journal club

Andrew Sursanto, AG König Schnurr

Park et al. Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis, Science 2024

Guest speaker

Dr. med. Sonja Wörmann

Group Leader, TUM University Hospital 

APOBEC3A - Driver of Chromosomal Instability and Metastasis in Pancreatic Cancer

Results colloquium

Sara Egea- Rodriguez, AG Helfrich

RECQL4-mediated downregulation of MHC class II promotes immune evasion and reduced anti-PD-1 response in melanoma patients

Journal club

Selin Aidin, AG Baldauf

Wen et al. Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression. Nature Communications 2024

Results colloquium

Lisa Gregor, AG Kobold

Ablation of prostaglandin E2 signaling through receptor knockouts enables CAR T cell therapy of solid tumors

Journal club

Vanessa Wittmann, AG Anz

Damasceno et al. STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program. Cell Reports 2022

Guest speaker

Prof. Dr. Dominik Wolf

Head of the Department of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck

Myeloid inflammation in health and cancer

Results colloquium

Linda Hammann, AG Anz

The impact of CCR4 ligands on tissue Treg cells in islet autoimmunity

Journal club

Daria Shvets, AG Kobold

Hänggi K et al. 2024 Interleukin-1a release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity. Cancer Cell 2024

Results colloquium

Julia Teppert, AG König Schnurr

Cell death-optimized 3p-RNAs for improved tumor immunotherapy

Journal club

Rasmus Müller, AG Kobold

Qiu et al. Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity. Cancer Cell 2024

Educational colloquium

Dr. med. vet. Charlotte Marx

High- Dimensional flow cytometry in cancer research 

Journal club

Helen Stirling, AG Rothenfußer

Singh et al. A Zika virus- specific lgM elicites in pregnany exhibits ultrapotent neutralization. Cell 2022

Results colloquium

Alexandra Leutbecher, AG Subklewe

Antibody-based immunotherapy for the treatment of epithelial ovarian cancer

Journal club

Distribution of team jobs for 2025

Stefan Niedermeier, AG Buchner

Baldwin et al. Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy. Cell 2024

Results colloquium

Dr. Ngoc-Thien-Thu Nguyen, AG Kobold

Immunotherapy in a case

Journal club

Lisa Gregor, AG Kobold

Cancelled

Results colloquium

Jan Gärtig, AG Anz

CCL22 - the root of all evil?

Journal club

Amelie Muth, AG Subklewe

Guerrero et al. GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency. Nature Communications 2024

Results colloquium

Rasmus Müller, AG Kobold

Serotonin receptor-induced trafficking of CAR T cells into solid tumors

Journal club

Julia Teppert, AG König/ Schnurr

Chibaya et al. Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer. Science Translational Medicine 2024

Results colloquium

Till Johannsmann, AG Daniel

Novel modulators of regulatory T cells to control autoimmunity vs cancer

Journal club

Alexandra Triebig, AG Kroiß

Van Elsas MJ et al. Immunotherapy-activated T cells recruit and late-stage activated M1-like macrophages that are critical for therapeutic efficacy. Cancer Cell 2024

Results colloquium

Stefan Niedermeier, AG Buchner

Tumor microenvironment remodeling and increased ferroptosis sensitivity during Richter Transformation

Journal club

Sabine Oganesian, AG Theurich

Gaydosik et al. The mycosis fungoides cutaneous microenvironment shapes dysfunctional cell trafficking, antitumor immunity, matrix interactions, and angiogenesis. JCI Insight 2023

Results colloquium

Emanuele Carlini, AG Kobold

Introducing a non-canonical IL-23R signalling into CSF-1R+ CAR-T cells

Journal club

Nilofer Abdul Razak, AG König/ Schnurr

Ng et al. Deterministic reprogramming of neutrophils within tumors. Science 2024

Results colloquium

Monika Sponheimer

TNF-alpha and IFN-gamma: The good and evil in CD70-directed NK cell based-Immunotherapy for AML

Journal club

Tanja Maier, AG Kroiß

Wilmouth et al. Sexually dimorphic activation of innate antitumor immunity prevents ACC development. Science Advances 2022

Results colloquium

Charlotte Carcopino, AG Kobold

Arming iPSC-derived NK cells with a chimeric antigen receptor for the treatment of acute myeloid leukemia

Journal club

Emanuele Carlini, AG Kobold

Zhu et al. A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma. Signal Transduct Target Therapy 2024

Results colloquium

Alejandro Salinas, AG Baldauf

Optimizing delivery of the lentiviral protein Vpx to overcome chemotherapy resistance in AML

Journal club

Jan Gärtig, AG Anz

Plebanek et al. A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression. Science Immunology 2024

Results colloquium

Emre Erdogan, AG Kobold

Development of a CAR that specifically and selectively recognizes AML blasts

Journal club

Alexandra Leutbecher, AG Subklewe

Huang et al. Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47. Nature Cancer 2024

Results colloquium

Sandra Dirschl, AG Daniel

Restoring impaired Treg cells by targeted miRNA modulation

Journal club

Adriano Carboniero, AG Teurich

Sun et al. Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation. Journal for ImmunoTherapy of Cancer 2023

Results colloquium

Viola Siegert, AG Buchner

Metabolic reprogramming during the transformation of CLL to aggressive lymphoma

Journal club

Alejandro Salinas, AG Baldauf

Chen et al. An oncolytic virus–T cell chimera for cancer immunotherapy, Nature Biotechnology 2024

Introduction, Team Jobs

Journal club

Viola Siegert, AG Buchner

Lu et al. SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells. Cell metabolism 2024

Results colloquium

Tanja Maier, AG Kroiß

Potential immune modulating factor in adrenocortical carcinoma (ACC)

Journal club

Giulia Rappa, AG Subklewe

Wolf et al. One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication. Clinical Cancer Research 2024

Results colloquium

Alexandra Triebig, AG Kroiß

Targeting macrophages in adrenocortical carcinoma (ACC) – impact of the TME and ferroptosis

Journal club

Linda Hammann, AG Anz

Döring et al. Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis”. Nature Cardiovascular Research 2024

Results colloquium

Jingke Tu, AG Theurich

The Characteristics of Obesity-Associated NK Cells deriving from Bone Marrow Hematopoietic Stem/Progenitor Cells

Results colloquium

David Andreu Sanz, AG Kobold

RoseTTAFold-generated mini binders replacing scFv for CAR T cell therapy

Journal club

Till Johannsmann, AG Daniel

Nakandakari- Higa et al. Universal recording of immune cell interactions in vivo. Nature 2024

Results colloquium

Amelie Muth, AG Subklewe

Modulating Bispecific Antibody-Mediated T Cell Exhaustion by Exposure to Glucocorticoids

Journal club

Rasmus Müller, AG Kobold

Zhao et al. IL-10 expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases. Nature Biotechnology 2022

Results colloquium

Dr. Sarah Kim-Hellmuth

The fascinating effects of genetic diversity on the human immune system and beyond

Journal club

Charlotte Carcopino, AG Kobold

Cancelled

Results colloquium

Sabine Oganesian, AG Theurich

Characterization of the Tumormicroenvironment in Cutaneous T cell Lymphoma with a special focus on B cells

Journal club

Mirjam Schobel, AG Rothenfußer/ Kim- Hellmuth

Cancelled

Results colloquium

Lisa Gregor, AG Kobold

Prostanoid- resistant CAR T cells in cancer

Journal club

Sara Egea- Rodriguez, AG Helfrich

Bawden et al. CD4+ T cell immunity against cutaneous melanoma encompasses multifaceted MHC II- dependent responses. Science Immunology 2024

Educational colloquium

Dr. Anne Holtermann, AG Kobold

Cancelled

Journal club

Sandra Dirschl, AG Daniel

Hamilton et al. In vivo human T cell engineering with enveloped delivery vehicles. Nature Biotechnology 2024

Educational colloquium

Dr. Ignazio Piseddu, AG Anz

Cancelled

Journal club

Emre Erdogan, AG Kobold

Corey et al. Novel engineered chimerif engulfment receptors trigger T cell effector functions against SIV-infectes CD4+ T cells. Molecular Therapy 2023

Results colloquium

Julia Teppert, AG König/ Schnurr

Cell death-optimized 5´-triphosphate RNAs for improved tumor immunotherapy

Journal club

Dr. Matthias Thaler, AG Anz

Mackensen et al. "Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus". Nature Medicine 2022

Results colloquium

Monika Sponheimer, AG Subklewe

The Yin and Yang of Pro-Inflammatory Cytokines in Antibody-based Immunotherapy of AML: TNF-a Increases the Expression of the Leukemia-Associated Antigen CD70, and IFN-g Dampens ADCC by NK Cells

Journal club

Alexandra Leutbecher, AG Subklewe

Tang et al. CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity. Nature Immunology 2023

Results colloquium

Sophie Bernhard, AG Kobold

Arming CAR T cells with C-C-motive receptor 8 for cancer treatment

Journal club

Dr. Matthias Thaler, AG Anz

Cancelled

Results colloquium

Stefan Niedermeier, AG Buchner

Exploring tumor microenvironment remodeling and ferroptosis resistance during Richter transformation

Journal club

Lena Jablonowski, AG Feuchtinger

Xiang et al. An "Off- the- Shelf" CD2 universal CAR- T therapy for T- cell malignancies. Leukemia 2023

Results colloquium

Till Johannsmann, AG Daniel

Novel inducers of Treg cells to control autoimmunity such as T1D

Journal club

Viktoria Hartmann, AG Kobold

Nils Wellhause et al. „Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy“. Science Translational Medicine 2023

Educational colloquium

Dr. Thu Nguyen, AG Kobold

Clinical aspects of CAR- T cell therapy

Journal club

Lena- Maria Jablonowski, AG Feuchtinger

Cancelled

Results colloquium

Alejandro Salinas- Illarena, AG Baldauf

Development of simplified virus- like particles (VLPs) for Vpx delivery to overcome chemotherapy resistance in AML

Journal club

Gordon Hoffmann, AG Kobold

Tousley et al. Co- opting signaling molecules enables logic- gated control of CAR T cells. Nature Cancer 2022

Results colloquium

Mara Henrich, AG Kobold

CAR-T cell therapy in colorectal cancer - Disease specific engineering of CAR-T Cells utilizing chemokine receptors

Journal club

Valerie Kolarik, AG König/ Schnurr

Swietlik et al: “Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation“. Nature Communications 2023

Results colloquium

Viola Siegert, AG Buchner

Metabolic Reprogramming during the transformation of CLL to aggressive lymphom

Journal club

Luana Messa, AG Anz

Tian et al “Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab- CCL5 fusion protein via innate and adaptive immunity“. Nature Cancer 2022

Results colloquium

Prof. Matthias Kroiß, AG Kroiß

What endocrine tumors can teach about cancer immunology

Journal club

Shenzhi Jia, AG Rothenfußer

Cancelled

Results colloquium

Tanja Maier, AG Kroiß

Towards an understanding of the microenvironment of ACC: Impact of steroid hormones and glucocorticoid receptor signaling

Journal club

Vivien Menkhoff, AG Kobold

Cancelled

Results colloquium

Antonio Santos del Peral, AG Rothenfußer

Basal determinatnts of immune variation and response to the yellow fever vaccine

Journal club

Till Johannsmann, AG Daniel

Zani et al. The dietary sweetener sucaralose is a negative modulator of T cell-mediated responses. Nature 2023

Results colloquium

Prof. Simon Rothenfußer, AG Rothenfußer

Lessons to learn from primary immunodeficiencies

Journal club

Paul Schwarzlmüller, AG Kroiß

Acharya et al. Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity 2020

Results colloquium

Sara Egea-Rodriguez, AG Helfrich

High levels of RECQL4 DNA helicase correlate with low numbers of tumor- infiltrating lymphocytes driving poor clinical outcome in patients of mal

Journal club

Lina Majed, AG Kobold

Zhang et al. Reprogramming tumor- associated macrophages to outcompete caner cells. Nature 2023

Results colloquium

Dr. Maike Buchner, AG Ruland, AG Buchner

Signaling thresholds in B cell development an CLL

Journal club

Jingke Tu, AG Theurich

Souza-Fonseca-Guimaraes et al. TGF-β and CIS Inhibition overcomes NK-cell suppression to restore antitumor immunity. Cancer Immunol 2022

Results colloquium

Phillip Müller, AG Kobold

Engineering of novel CAR T cells- Targeting lung cancer specific structures

Journal club

Lina Majed, AG Kobold

How to hold a journal club

(Guideline)

Results colloquium

Alexandra Triebig, AG Kroiß

Targeting the Ferroptosis-Macrophage crosstalk in adrenocortical carcinoma (ACC)

Journal club

Stefan Niedermeier, AG Buchner

Choi et al. Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity. Science Immunology 2023

Results colloquium

Sandra Dirschl, AG Daniel

T cell specific miRNA targeting in Type 1 Diabetes

Journal club

Mirjam Schobel, AG Rothenfußer und Kim-Hellmuth

Hagan et al. Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. Nat Immunol 2022

Results colloquium

Adriano Carboniero, AG Theurich

Metabolic reprogramming of Natural Killer cells by obesity-associated and tumour-derived cytokine networks

Journal club

Sara Egea-Rodriguez, AG Helfrich

Wang et al., STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer. Nature Communications 2022

Results colloquium

Amelie Muth, AG Subklewe

Lenalidomide in combination with continuous CD3xCD19 T cell recruiting bispecific antibody treatment maintains T cell function and delays exhaustion

Journal club

Alejandra Hernandez Caceres, AG Hopfner

Yu, X. et al. Reducing affinity as a strategy to boost immunomodulatory antibody agonism. Nature 2023

Results colloquium

Dr. Iman Dalloul, AG Kobold

Canonical Switch in Cis or Trans and IgH Locus Suicide Recombinations

Journal club

Alexandra Leutbecher, AG Subklewe

J. Ding et al. Mesothelin targeting T cells bearing a novel T cell receptor fusion construct TRuC exhibit potent antitumor efficacy against solid tumors. OncoImmunology 2023

Results colloquium Kick-off i-Target 2.0

Emanuele Carlini, AG Kobold

Engineering an atypical cytokine signalling into human CSF-1-responsive CAR T cells