Autoinflammation and adverse cutaneous drug reactions
Main fields of research
The aim of our research is to better understand key molecular events and targets that mediate inflammatory skin diseases with a focus on neutrophilic skin diseases and adverse cutaneous drug reactions. We are particularly interested in i) the immune responses and driver cytokines involved in cutaneous adverse drug reactions including Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN) and epidermal necrolysis induced by checkpoint inhibitors; and ii) the immune responses specifically involved in neutrophilic dermatoses such as hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG). Using bulk and single cell transcriptomes, proteomics, biochemical and cell biology technologies, we investigate the molecular pathogenesis of inflammatory skin diseases with the aim of deciphering disease heterogeneity (endotypes) and defining new therapeutic targets as well as precision medicine approaches to diagnosis and management.