Project Group Stem Cells
Head: Dr. rer. nat. Sabrina Galinski
Research Interests: Stem cell-based cell systems from patients with psychiatric disorders
Psychiatric disorders are subject to highly complex gene regulation in which multiple hereditary risk factors and spontaneously altered sections of the genome probably interact to cause the disease. Genetic model systems with complete ‘construct validity’ can therefore only be derived from individual patients. The development of reprogramming technology for the production of so-called induced pluripotent stem cells (iPSCs) from blood samples of adults, combined with protocols to differentiate neuronal cell systems, like complex 3D models, now offers this possibility. Our aim is to apply these ‘personalised cellular model systems’ and to determine a divergent molecular signature or individual disease profile, by using for example genetic reporter systems or electrophysiological measurements. In the next step, we plan to test approved agents or combinations of agents to bring the individual disease profile as close as possible to the reference profiles of healthy individuals. With this strategy we aim to identify new approaches for the treatment of psychiatric disorders.
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- Raabe FJ, Galinski S, Papiol S, Falkai PG, Schmitt A, Rossner MJ. Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems. NPJ Schizophr. (2018) 4(1).
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