Medical Clinic and Polyclinic I
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AG Thienel/Petzold

The aim of our research group is to gain a better understanding of cardiovascular diseases in order to uncover new mechanisms of antiplatelet therapy and thus enable individualized patient treatment. On the one hand, we are investigating platelet formation in the bone marrow and its influence on cardiovascular diseases. On the other hand, we are analyzing the role of platelets during atherothrombosis as a correlate for ischemic events such as myocardial infarction. In a translational "bedside-to-bench" approach, we try to answer clinically relevant questions by analyzing samples from patients as well as performing in vivo mouse models using state-of-the-art imaging techniques. In one of our current projects, for example, we were able to show that direct oral anticoagulants (DOACs), a frequently administered group of drugs, have a coagulation-independent, so-called non-canonical effect on platelets.
LMU Klinikum
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