Functional Neuroimaging
Group Leader
Prof. Dr. med. Sophia Stöcklein
Senior physician, head of MRI, head of research organisation
Clinical and Postdoctoral Researchers
Dr. med. Gloria Biechele
Resident
PD Dr. med. Sarah Schläger
Resident
Stefan Carl
Resident
Stefan is a radiology resident with a previous research focus and passion for neurofunctional imaging. As part of his doctoral thesis at the Klinikum rechts der Isar, he investigated the growth behavior of gliomas and the effects of radiotherapy on the functional status of patients in terms of motor or language deficits. Cortical functional imaging using transcranial magnetic stimulation (TMS) was combined with DTI via fiber tracking and correlated with radiotherapy.
Dr. med. Stephan Wunderlich, M.Sc.
Postdoctoral researcher
With a multidisciplinary background in medicine and engineering from TUM, the Martinos Center for Biomedical Imaging in Boston, the Brain Science Center in Edinburgh, and the University of British Columbia, Stephan’s research passion lies at the intersection of technical methodologies and medicine. He specializes in health data analytics and functional neuroimaging using artificial intelligence methods.
Dr. Adyasha Tejaswi Khuntia
Postdoctoral researcher
Adyasha’s work focuses on building a normative reference database of functional connectivity and on developing machine learning models that identify individual deviations from this healthy baseline. She completed her PhD at the Clinic for Psychiatry and Psychotherapy, LMU Munich, within the International Max Planck Research School for Translational Psychiatry. Her doctoral work investigated the biological signatures of somatic comorbidities in psychiatric disorders and developed tools for comorbidity-informed stratification of patients with mental illness.
Dr. Mahnaz Ashrafi Varnosfaderani
Postdoctoral researcher
Mahnaz completed her academic degrees in Electrical Engineering and moved into the field of neuroimaging during her Ph.D., where she focused on computational modeling and functional connectivity analysis. She subsequently joined the Department of Neuroradiology at TUM as a postdoctoral researcher, where she worked with multimodal fMRI and PET data and developed a multilayer framework for constructing a metabolism-weighted brain connectome. She now continues to work with multimodal imaging data, with a particular focus on Alzheimer’s disease.
PhD and MD students
Mariyana Cholakova
Mariyana is a PhD student at the Graduate School of Systemic Neurosciences (GSN) with a background in artificial intelligence and neuro-engineering. Her research focuses on applying machine learning and computational modeling to investigate large-scale brain dynamics using functional MRI, with a particular interest in how changes in brain dynamics relate to cognitive function and neurological disease.
Artur Toloknieiev
A doctoral medical student and programmer autodidact, Artur brings to the table a profound understanding of the physiology behind the clinical pictures and a wealth of skill in software engineering with a focus on artificial intelligence. He works on machine learning and data operations, communicates with engineers on medical aspects of the technology and works on the optimization data acquisition, data enrichment and model training processes.
Junlin Jing
Junlin is a PhD student whose previous research focused on machine learning and the application of ICA-derived approaches to functional neuroimaging and structural connectivity. He is currently working on the use of machine learning to investigate abnormal functional connectomes of neurological and psychiatric disorders, particularly in personalized diagnosis.
Undergraduate students
Mohammad Saeed Motevali
A computer science student specializing in medical image processing and analysis. His research focuses on developing algorithms for processing and analyzing fMRI data, with a particular emphasis on machine learning applications in medical diagnostics. His work combines expertise in computational methods with practical applications in abnormality detection, aiming to improve diagnostic capabilities through automated analysis of neural imaging data. He is particularly interested in developing robust machine learning and deep learning frameworks for processing complex neurological data and identifying patterns that can aid in the early detection of neurological conditions through fMRI analysis.
Technicians
Boris Papazov
Boris received his Bachelor of Science in the field of Engineering Physics and his Master of Science in the field of Aerospace Engineering Sciences. He currently organizes, optimizes, and performs clinical research MRI scans with a focus on fMRI and brain tumors.
Claudia Dietz
Claudia is a radiology assistant with long-standing experience working with oncology patients in magnetic resonance imaging. Throughout her career, she has developed extensive expertise in MRI examinations and in supporting patients throughout their imaging journey.
Scientific Project Management
Dr. Ana Martins
Ana has a background in molecular medicine and provides scientific and administrative support to the team.
Alumni
Franziska Müller
Tobias Prester
Hlib Kholodkov
Dmytro Voitsekhivskyi
Roman Lvovich
The Functional Neuroimaging Group focuses on the assessment of the “individual brain connectome” based on resting-state functional magnetic resonance imaging (fMRI). We work on algorithms to detect and quantify changes in the functional connectivity architecture of individual patients in comparison to large reference cohorts, with the overarching aim to develop imaging biomarkers for diagnosis, treatment monitoring and therapy guidance of neurological and neuropsychiatric disorders. Our main focus comprises neuro-oncological and neuro-degenerative diseases. In order to better understand the adult brain, our group further uses advanced MRI techniques to study brain development perinatally, including fetal and neonatal imaging of the brain, and organ systems that impact brain development such as the cardio-respiratory system.
Our interdisciplinary group is composed of radiologists, neurobiologists, psychologist, engineers, and computer scientists.
Functional connectivity in neurological disorders
New concepts of brain disease suggest that network disruption does not only occur as an epi-phenomenon of underlying brain pathology, but that the formation of aberrant connections can be a major contributor to the progression of brain diseases, including neuro-oncological and neurodegenerative diseases. The current role of MRI in such diseases is to provide structural information about tumors and their close vicinity and to describe patterns of brain atrophy and vascular damage. Here, assessment of functional connectivity alterations on the whole brain level might provide important additional information that is not yet available in vivo in individual patients.
However, despite more than two decades of functional connectivity research no clinically applicable and validated imaging tool is available to assess network dysfunctions quantitatively in the individual patient. We have designed a novel imaging marker based on resting-state fMRI which assesses global functional connectivity in individual patients (Stoecklein et al., 2020), with the aim to detect and quantify alterations of the connectivity architecture of individual patients by comparing individual connectivity profiles to a normative distribution derived from large, healthy reference cohorts.
Neuro-oncology
Building on our long-standing work on patient-level functional connectivity mapping, our group is currently advancing these concepts toward clinical translation in neuro-oncology through the ERC Consolidator project CONNECT.
CONNECT - an ERC Consolidator project
Recent advances in cancer neuroscience show that malignant brain tumors such as glioblastoma extend far beyond the visible lesion and interact with brain-wide neuronal circuits. By forming synaptic connections with neurons, tumors can exploit neural activity to support their growth, strongly influencing disease progression.
With the ERC Consolidator project CONNECT (Cutting-Edge Neuroimaging for Functional Brain Network Evaluation in Cancer Patients), we aim to translate these insights into clinical imaging by establishing functional connectivity MRI as a quantitative tool for cancer diagnostics.
Central to the project is the construction of a large-scale reference database comprising thousands of fMRI datasets. Leveraging this resource, we will develop AI-supported methods to map and quantify patient-specific network deviations. These imaging findings will be linked to structural connectivity and molecular tumor profiles, enabling mechanistic insight into tumor–brain interactions.
The clinical potential of this approach will be evaluated in two independent patient cohorts. By identifying network changes that may precede visible tumor progression, CONNECT aims to enable earlier detection of recurrence or metastasis and to inform more precise, network-oriented therapeutic strategies.
Neurodegeneration
Recent advances in functional neuroimaging highlighted disruptions in brain network in neurodegenerative disorders such as Alzheimer’s Disease, and Parkinson’s Disease. We aim to develop a functional imaging marker that predicts disease progression and assesses treatment response. Recent publications suggest the propagation of neurodegenerative pathology, e.g., tau spread, through functional brain network disruptions.
Artificial intelligence for data analysis of large cohort studies
Perinatal imaging: Advanced MR imaging for the exploration of brain development in health and disease
ALZECA
Alzheimer's disease is characterized by the presence of amyloid plaques - protein depositions - in the brain. Currently, assessing amyloid presence and distribution in the brain requires positron emission tomography (PET). The aim of the ALZECA study is to determine whether this procedure may be replaced by magnetic resonance imaging (MRI) using the contrast agent ADx-001. ADx-001 is a novel, intravenously delivered, Gd-containing molecularly targeted liposomal product that is being developed for use in contrast-enabled MR imaging of amyloid plaques.
Replacing PET by MRI would reduce radiation exposure and simplify the diagnostic process by providing detailed information on brain structure and volume while simultaneously identifying amyloid depositions. Animal studies have shown that ADx-001 accumulates in brain regions with amyloid plaques and is detectable by MRI (Badachhape et al., 2020). The objective of this Phase 1 trial is to establish safety of ADx-001 in healthy volunteers, and safety and proof of concept in patients with confirmed amyloid plaques in the brain (confirmed by amyloid PET).
Badachhape, A.A., Working, P.K., Srivastava, M. et al. Pre-clinical dose-ranging efficacy, pharmacokinetics, tissue biodistribution, and toxicity of a targeted contrast agent for MRI of amyloid deposition in Alzheimer’s disease. Sci Rep 10, 16185 (2020)
Selected publications
Stoecklein VM, Wunderlich S, Weller J, Papazov B, Suvak S, Katzendobler S, Schmutzer-Sondergeld M, Schichor C, Thon N, Von Baumgarten L, Kalasauskas D, Harter PN, Ricke J, Liebig T, Ringel F, Stoecklein S. Disturbance of functional connectivity in patients with low grade glioma is associated with worse progression–free survival. Neuro-Oncology Advances. 2026;8(1):vdag051.
Wunderlich S, Alici C, Motevalli S, Stoecklein V, Von Baumgarten L, Schöberl F, Subklewe M, Schulz E, Stoecklein S. Denoising strategies of functional connectivity MRI data in lesional and non-lesional brain diseases. Imaging Neuroscience. 2025;3:IMAG.a.968.
Biechele G, Koliogiannis V, Rennollet P, Prester T, Schulz E, Kolben T, Jegen M, Hübener C, Hasbargen U, Flemmer A, Dietrich O, Burkard T, Schinner R, Dinkel J, Muenchhoff M, Hintz S, Delius M, Mahner S, Ricke J, Hilgendorff A, Stoecklein S. Preserved prenatal lung growth assessed by fetal MRI in the omicron-dominated phase of the SARS-CoV-2 pandemic. Eur Radiol. 2024;35(3):1514-1521.
Stoecklein S, Wunderlich S, Papazov B, Winkelmann M, Kunz WG, Mueller K, Ernst K, Stoecklein VM, Blumenberg V, Karschnia P, Bücklein VL, Rejeski K, Schmidt C, von Bergwelt-Baildon M, Tonn JC, Ricke J, Liu H, Remi J, Subklewe M, von Baumgarten L, Schoeberl F. Functional connectivity MRI provides an imagingcorrelate for chimeric antigen receptor T-cell-associated neurotoxicity. Neurooncol Adv 2023 Oct 24;5(1).
Stoecklein S*, Koliogiannis V*, Prester T, Kolben T, Jegen M, Hübener C, Hasbargen U, Flemmer A, Dietrich O, Schinner R, Dinkel J, Fink N, Muenchhoff M, Hintz S, Delius M, Mahner S, Ricke J, Hilgendorff A. Effects of SARS-CoV-2 on prenatal lung growth assessed by fetal MRI. Lancet Respir Med 2022 Apr;10(4):e36-e37 *shared first.
Stoecklein VM*, Stoecklein S*, Galiè F, Ren J, Schmutzer M, Unterrainer M, Albert NL, Kreth FW, Thon N, Liebig T, Ertl-Wagner B, Tonn JC, Liu H. Resting-state fMRI Detects Alterations in Whole Brain Connectivity Related to Tumor Biology in Glioma Patients. Neuro Oncol 2020 Sep 29;22(9):1388-1398 *shared first.
Stoecklein S, Hilgendorff A, Li M, Förster K, Flemmer AW, Galiè F, Wunderlich S, Wang D, Stein S, Ehrhardt H, Dietrich O, Zou Q, Zhou S, Ertl-Wagner B, Liu H. Variable functional connectivity architecture of the preterm human brain: Impact of developmental cortical expansion and maturation. Proc Natl Acad Sci U S A 2020 Jan 14;117(2):1201-1206.
Mueller S, Wang D, Fox MD, Yeo BT, Sepulcre J, Sabuncu MR, Shafee R, Lu J, Liu H. Individual variability in functional connectivity architecture of the human brain. Neuron 2013 Feb 6;77(3):586-95.
Full publication list
The Functional Neuroimaging group currently receives research funding by
European Research Council
Netzwerk Universitätsmedizin
Medical Faculty of the LMU
Deutsche Gesellschaft für Muskelkranke e.V.
Bruno und Helene Jöster Stiftung
Brainlab AG
Deutsches Zentrum für Lungenforschung (DZL)
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Helmholtz Zentrum München
Hôpital Necker-Enfants malades, Paris
Medizinische Universität Wien, Abteilung für Neuroradiologie und muskuloskelettale Radiologie
Northh Medical
Institut für Neuropathologie, LMU
Brustzentrum, LMU Klinikum
Institut für Schlaganfall- und Demenzforschung (ISD), LMU Klinikum
Klinik für Psychiatrie und Psychotherapie, LMU Klinikum
Klinik und Poliklinik für Neurologie, LMU Klinikum
Medizinische Klinik und Poliklinik V, LMU Klinikum
Neurochirurgische Klinik und Poliklinik, LMU Klinikum